This guidance document was developed by Ms. Julie Dowler, Ms. Denise Reniers and Ms. Anne Chambers, Children’s Hospital, London Health Sciences Centre, London. Reviewed in consultation with Ms. Lisa Honeyford, The Hospital for Sick Children, Ms. Kirsty Morelli, Scarborough Health Network, Centenary Hospital and Ms. Mary Jo De Courcy, Children’s Hospital, London Health Sciences Centre, based on the sources below.
- B.C. Cancer Agency Policy III-20, Extravasation of Chemotherapy, Prevention and Management of, Revised January 2016, Approved by Provincial Systemic Program Committee.
- Cancer Care Ontario, Safe Administration of Systemic Cancer Therapy Part 2: Administration of Systemic Treatment and Management of Preventable Adverse Events (November 2018, version 2). Retrieved December 2020, https://www.cancercareontario.ca/en/guidelines-advice/types-of-cancer/1201
- Fabian, B. Intravenous complications: Infiltration. Journal of Intravenous Nursing 2000; 23(4):229-31.
- Froland, K. Extravasation injuries. J WOCN 2007; 34 (3): 299-302.
- Hooke MC. Clinical nurse specialist and evidence-based practice: Managing anthracycline extravasation. Journal of Pediatric Oncology Nursing 2005; 22(5): 261-4.
- Kassner E. (2000). Evaluation and treatment of chemotherapy extravasation injuries. Journal of Pediatric Oncology Nursing 2000 Jul; 17(3):135-48.
- Langer SW, Sehested M, Jensen PB. Treatment of anthracycline extravasation with dexrazoxane. Clin Cancer Res; 2000; 6: 3680-86.
- Llinares ME, Bermudez M, Fuster JLet al. Toxicity to topical dimethyl sulfoxide in a pediatric patient with anthracycline extravasation. Pediatric Hematology and Oncology 2005;22(1):49-52.
- London Health Sciences Centre Formulary, Chemotherapy Extravasation Management Protocol. London, ON, Canada, Revised May 2011, Approved by Drugs and Therapeutics Committee.
- Mader I, Furst-Weger PR, Mader R, et al. Amsacrine. In: Mader I, ed. Extravasation of cytotoxic agents: Compendium for prevention and management. Vienna, Austria: Springer; 2003. p.59-60.
- Medication Extravasation, Treatment of, Clinical Standards Manual, Children’s Hospitals and Clinics, Minneapolis/St. Paul, Minnesota, Feb 11, 2005, page: E-105.1-105.6.
- Mouridsen HT, Langer SW, Buter J, et al. Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies. Ann Oncol 2007; 18(3): 546-50.
- Olver IN, Aisner J, Hament A. et al. A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation. J Clin Oncol 1988; 6(11):1732-35.
- Perez Fidalgo JA, Garcia Fabregat L, Cervantes A, et al. Management of chemotherapy extravasation: ESMO-EONS Clinical Practice Guidelines. Ann Oncol 2012; 23(Suppl 7): vii167-73.
- Pizzo PA, Poplack DG (eds). Local treatment for chemotherapy extravasation. In: Principles and Practice of Pediatric Oncology, Table 44-7. Lippincott Williams & Wilkins, United States 2002.
- Polovich M, Whitford JM, Olsen M, eds Chemotherapy and Biotherapy Guidelines and Recommendations for Practice.,3rd ed. Pittsburg, PA: Oncology Nursing Society; 2009. p. 105-10.
- Sauerland, C, Engelking, C, Wickham, R, et al. Vesicant Extravasation Part 1: Mechanisms, Pathogenesis and Nursing Care to Reduce Risk. Oncol Nurs Forum 2006; 336(6) 1134-41.
- Schulmeister, L. Preventing and managing vesicant chemotherapy extravasations. J Support Oncol 2010; 8(5): 212-15.
- Schulmeister, L and Camp-Sorell, D: Chemotherapy extravasation from implanted ports. Oncol Nurs Forum 2000; 27: 531-38.
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Record of Updates
|Version Number||Date of Effect||Summary of Revisions|
|1||6/28/2021||Original version posted.|