Understanding Acute GVHD: Linking Clinical Science to the Bedside

Presentation Description:  Graft versus host disease (GVHD) remains the major complication of allogeneic bone marrow transplantation (BMT), but until recently there have been no laboratory biomarkers for GVHD.  One new plasma biomarker for GVHD of the gastrointestinal tract, Regenerative 3c (REG3o), has significant diagnostic and prognostic value.  This presentation described one approach to the discovery and validation of such biomarkers and analyzed their potential for use in developing new grading schemes with improved risk-stratification of patients.


James L.M. Ferrara, MD, DSc.
Combined Adult and Pediatric Blood and Marrow Transplant Program
University of Michigan Cancer Center, Michigan, USA

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