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POGO > Blog > MIBG
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Tag: MIBG


New & Now – Four Innovative Studies that are Changing the Landscape of Care

Posted on March 4, 2014 by admin


Presentation Description:
This presentation highlighted four innovative studies that are having a major impact on the diagnosis and/or treatment of childhood cancer.

Impact of Ethnicity on the Donor Search for Pediatric Patients Considered for Stem Cell Transplantation

Speaker:
Julia DiLabio, MSc, MD Candidate
University of Toronto, Toronto

Neuropathic Pain Related to Vincristine: A Pediatric Descriptive Study

Speakers:
Catherine Goudie, MD
Fellow in Pediatric Hematology-Oncology
McGill University, Montreal

Christine Racette, MD
Pediatric Resident
Laval University, Quebec City

Bringing 131I-MIBG Therapy Closer to Home

Speaker:
Denise Mills, RN(EC), MN, NP Pediatrics, CPN, ACNP
Division of Haematology/Oncology
The Hospital for Sick Children, Toronto

Relations Among Anxiety and Depression, Autonomy and Mothers’ Overprotective Parenting Practices in Young Adult Survivors of Childhood Cancer

Speaker:
Amanda Sherman, MA, PhD Candidate
Department of Psychology, University of Toronto, Toronto
POGO Research Fellow

Posted in 2013 Symposium - Innovation in Pediatric Oncology, Education for Health Professionals | Tagged 2013 Symposium, adolescents, anxiety, ethnicity, MIBG, neuropathic pain, parents, Pediatric Stem Cell Transplantation

131I- MIBG Therapy: Living in a Lead-Lined World

Posted on March 4, 2014 by admin


Presentation Description:
Despite advances in the treatment of high-risk neuroblastoma, cure rates remain <50% with neuroblastoma accounting for 15% of all pediatric oncology deaths (Maris, 2007, 2010). In Canada, there are 60-70 children newly diagnosed with neuroblastoma each year, with 50% of these cases being stage IV disease (Canadian Cancer Society, 2008).  Although most patients with stage IV high risk disease respond to front-line therapy, 50-60% will relapse and the prognosis for these children remains poor, with most dying from progressive disease. These children often suffer tumor related pain and undergo frequent cycles of chemotherapy for disease control, resulting in side effects such as febrile neutropenia, and many visits to hospital for supportive and follow up care.  The literature describes that 131I- MIBG therapy is effective in the treatment of refractory and relapse disease although is not a cure.  In a large multi-institutional phase 2 trial examining 131I-MIBG as monotherapy Matthay et al, concluded that this targeted radionuclide is highly active and effective in the treatment of refractory or relapse high risk neuroblastoma with an overall complete plus partial response rate of 36%.

Access for Canadian families has been limited by a lack of Canadian 131I- MIBG facilities. Currently there is only 1 center in Canada and approximately 10 in the US that offer this therapy, and as a result families seeking 131I-MIBG therapy travel long distances to receive this treatment. As a leader in research and innovation SickKids gained approval for the construction and implementation of a 131I-MIBG therapy suite on the inpatient haematology/oncology unit. This presentation provided an overview of the planning, development and implementation of the 131I-MIBG program at SickKids.

Speakers:
Denise Mills, RN(EC), MN, NP
Nurse Practitioner, Division of Haematology/Oncology
The Hospital for Sick Children, Toronto
Lawrence S. Bloomberg Cross Appointment at Faculty of Nursing
University of Toronto, Toronto

Sharleen Sawicki, RN, BScN, CPHON
Registered Nurse, Division of Haematology/Oncology
The Hospital for Sick Children, Toronto

Posted in 2013 Pre-Symposium Nursing Seminar - Innovation in Pediatric Oncology Nursing, Education for Health Professionals | Tagged 2013 Pre-Symposium Nursing Seminar, MIBG, neuroblastoma, relapse

Quick Hit – MIBG:Indications, Side Effects, Monitoring and Follow-Up

Posted on February 7, 2013 by admin

Presentation Description: Neuroblastoma is the most common extracranial malignant tumour of childhood and accounts for 15% of all pediatric cancer deaths. On diagnosis, 50% of the children present with metastatic disease. Despite the intensive multimodality therapy, patients with high-risk neuroblastoma have a less than 40% survival rate. It is known that refractory or relapsed neuroblastoma is extremely difficult to treat. Treatment with Iodine-131 – labeled meta-iodobenzylguanidine (131 I-MIBG) has shown to be safe and efficacious in patients with progressive, refractory or relapsed high-risk neuroblastoma. This quick- hit presentation briefly described Indications of 131I-MIGB therapy, side effects, monitoring and supportive care of the patient and family.

Speaker:
Denise Mills, MN, RN(EC)
Nurse Practitioner
The Hospital for Sick Children, Toronto, ON

Posted in 2012 Satellite Education Day, Education for Health Professionals | Tagged 2012 Satellite Education Day, MIBG, neuroblastoma

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