2.2.2 Children Not Eligible for Chemotherapy Administration in a Satellite Centre

Eligibility for Chemotherapy Administration in a Satellite Centre is constrained by:

1. Children of any age whose disease demands high intensity, ongoing, rapidly progressing inpatient chemotherapy. Exceptions are as follows:
   1. Where the protocol specified therapy, at any time, falls within the individual agent guidelines, ( e.g. vincristine administration) or is deemed no more toxic than agents already specified as acceptable;
   2. As new chemotherapy agents become available and are used on protocol, their toxicities and their appropriateness for use in the satellite context will have to be evaluated; new agents may then be added, as appropriate, to the Table of Antineoplastic Agents approved for administration in the satellite context and suitable knowledge transfer undertaken;
   3. Administration of chemotherapy agents to patients with end stage disease (e.g. neuroblastoma, relapsed AML) which are palliative to ease the burden of care for families.
2. Children who have experienced significant, immediate toxicity with a given chemotherapeutic agent, e.g. anaphylactic reaction, seizures, cerebral edema.
3. Children who have undergone HPSCT transplant until specifically approved by the transplant center