This guideline provides physicians, nurses, pharmacists and other health care providers who care for children aged 1 month to 18 years who are receiving antineoplastic medication with an approach to assess the emetogenic potential of antineoplastic regimens. The scope of this guideline is limited to the assessment of antineoplastic therapy emetogenicity in the acute phase (within 24 hours of administration of an antineoplastic agent). Its scope does not include anticipatory, breakthrough or delayed phase antineoplastic-induced nausea and vomiting (AINV), or nausea and vomiting that is related to radiation therapy, disease, co-incident conditions or end-of-life care. In addition, this guideline is most applicable to children who are naïve to antineoplastic therapy and who are about to receive their first course of antineoplastic therapy. In the case of children who have received antineoplastic medication in the past, estimation of the emetogenic potential of the antineoplastic regimen to be given incorporates both the recommendations of this guideline and an assessment of the child’s previous experience with AINV.
This guideline represents the first of a series of guidelines to address the need for, and the selection of, antiemetic prophylaxis and intervention in children with cancer receiving antineoplastic therapy. These guidelines will lead to improvements in the supportive care of children with cancer by offering a standardized, evidence-based approach to the prophylaxis of AINV, optimization of AINV control and provision of cost-effective antiemetic prophylaxis.