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POGO > Healthcare Practice > COVID-19 Updates > COVID-19 Research Articles > COVID-19 General Pediatrics Articles > Epidemiology and Clinical Characteristics
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Epidemiology and Clinical Characteristics

**Disclaimer**  The articles listed are for information purposes only. POGO was not involved in the development or publication of these articles and posting does not indicate endorsement.

NOTE:  Due to the availability of other general pediatric COVID-19 resources and POGO’s mandate, this section will no longer be updated. COVID-19 studies relating to pediatric cancer will continue to be updated regularly.

Last Update: May 29, 2020

General Pediatrics – Primary Studies

  • Almeida, F. J., et al. (2020). Hematuria Associated With SARS-CoV-2 Infection in a Child. Pediatr Infect Dis J. doi:10.1097/inf.0000000000002737
  • Andina, D., et al.  (2020). Chilblains in children in the setting of COVID-19 pandemic. Pediatr Dermatol. doi:10.1111/pde.14215
  • Bai, K., et al. (2020). Clinical Analysis of 25 Novel Coronavirus Infections in Children. Pediatr Infect Dis J. doi:https://dx.doi.org/10.1097/INF.0000000000002740
  • Belhadjer, Z., et al. (2020). Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. doi:https://dx.doi.org/10.1161/CIRCULATIONAHA.120.048360
  • Brambilla, I., et al. (2020). COVID-19 in the Pediatric Population Admitted to a Tertiary Referral Hospital in Northern Italy: Preliminary Clinical Data. Pediatr Infect Dis J. doi:https://dx.doi.org/10.1097/INF.0000000000002730
  • Bush, R., et al. (2020). Mild COVID-19 in a pediatric renal transplant recipient. Am J Transplant. doi:https://dx.doi.org/10.1111/ajt.16003
  • Cai, J et al. (2020). A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. doi:10.1093/cid/ciaa198
  • Chao, J. Y., et al. (2020). Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 (COVID-19) at a Tertiary Care Medical Center in New York City. J. Pediatr. doi:https://dx.doi.org/10.1016/j.jpeds.2020.05.006
  • Chen, H. R., et al. (2020). A Case of Childhood Covid-19 Infection with Pleural Effusion Complicated by Possible Secondary Mycoplasma Pneumoniae Infection. Pediatr Infecti Dis J. doi.org/10.1097/INF.0000000000002721
  • Chen, J., et al. (2020). The clinical and immunological features of pediatric COVID-19 patients in China. Genes Dis. doi.org/10.1016/j.gendis.2020.03.008
  • Climent, F. J., et al. (2020). Fatal outcome of COVID-19 disease in a 5-month infant with comorbidities. Rev Esp Cardiol (Engl Ed). doi:https://dx.doi.org/10.1016/j.rec.2020.04.011
  • Colonna, C., et al. (2020). Chilblains-like lesions in children following suspected Covid-19 infection. Pediatr Dermatol. doi.org/10.1111/pde.14210
  • Craver, R., et al. (2020). Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c). Fetal Pediatr Pathol, 1-6. doi:10.1080/15513815.2020.1761491
  • Dong, Y., et al. (2020). Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China. Pediatrics. doi:10.1542/peds.2020-0702
  • Du, W., et al. (2020). Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. Infection. doi.org/10.1007/s15010-020-01427-2
  • Duramaz, B. B., et al. (2020). Appearance of Skin Rash in Pediatric Patients with COVID-19: Three Case Presentations. Dermatol Ther, e13594. doi:https://dx.doi.org/10.1111/dth.13594
  • Feld, L., et al. (2020). A Case Series of the 2019 Novel Coronavirus (SARS-CoV-2) in Three Febrile Infants in New York. Pediatrics, doi:https://dx.doi.org/10.1542/peds.2020-1056
  • Garazzino, S., et al. (2020). Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020. Euro Surveill, 25(18). doi:10.2807/1560-7917.es.2020.25.18.2000600
  • Giacomet, V., et al. (2020). Acute inflammation and elevated cardiac markers in a two-month-old infant with severe acute respiratory syndrome coronavirus 2 infection presenting with cardiac symptoms. Pediatr Infect Dis J. doi:10.1097/inf.0000000000002750
  • Garcia-Lara, G., et al. (2020). Chilblain-like lesions in pediatrics dermatological outpatients during the COVID-19 outbreak. Dermatol Ther, e13516. doi.org/10.1111/dth.13516
  • Han, Y. N., et al. (2020). A comparative-descriptive analysis of clinical characteristics in 2019-Coronavirus-infected children and adults. J Med Virol. doi: 10.1002/jmv.25835
  • Heilbronner, C., et al. (2020). Patients with Sickle cell disease and suspected COVID-19 in a pediatric ICU. Br J Haematol. doi:https://dx.doi.org/10.1111/bjh.16802
  • Huang, L., et al. (2020). Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside Wuhan and characteristics of young patients with COVID-19: a prospective contact-tracing study. J Infect. doi 10.1016/j.jinf.2020.03.006 
  • Li, H., et al. (2020). The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia. J Infect. doi:10.1016/j.jinf.2020.04.001
  • Locatelli, A. G., et al. (2020). Histologic features of long lasting chilblain-like lesions in a pediatric COVID-19 patient. J Eur Acad Dermatol Venereol. doi:10.1111/jdv.16617
  • Lu, X., et al. (2020). SARS-CoV-2 Infection in Children. N Engl J Med. doi:10.1056/NEJMc2005073
  • Ma, H., et al. (2020). A single-center, retrospective study of COVID-19 features in children: a descriptive investigation. BMC Medicine, doi:https://dx.doi.org/10.1186/s12916-020-01596-9
  • Mao, L. J., et al. (2020). A child with household transmitted COVID-19. BMC Infect Dis., 20(1), 329. doi.org/10.1186/s12879-020-05056-w
  • Meslin, P., et al. (2020). Coronavirus Disease 2019 in Newborns and Very Young Infants: A Series of Six Patients in France. Pediatr Infecti Dis J. doi:https://dx.doi.org/10.1097/INF.0000000000002743
  • Michelena, X., et al. (2020). Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs. Semin Arthritis Rheum. doi:https://dx.doi.org/10.1016/j.semarthrit.2020.05.001
  • Morand, A., et al. (2020). Child with liver transplant recovers from COVID-19 infection. A case report. Arch Pediatr. doi:https://dx.doi.org/10.1016/j.arcped.2020.05.004
  • Nathan, N., et al. (2020). Atypical presentation of COVID-19 in young infants. Lancet. doi:10.1016/s0140-6736(20)30980-6
  • Oberweis, M. L., et al. (2020). Pediatric Life-Threatening Coronavirus Disease 2019 With Myocarditis. Pediatr Infect Dis J. doi:10.1097/inf.0000000000002744
  • Pain, C. E., et al. (2020). Novel paediatric presentation of COVID-19 with ARDS and cytokine storm syndrome without respiratory symptoms. Lancet Rheumatol. doi:https://dx.doi.org/10.1016/S2665-9913(20)30137-5
  • Parri, N., et al. (2020). Children with Covid-19 in Pediatric Emergency Departments in Italy. N Engl J Med. doi:10.1056/NEJMc2007617
  • Patel, P. A., et al. (2020). Severe Pediatric COVID-19 Presenting With Respiratory Failure and Severe Thrombocytopenia. Pediatrics. doi:10.1542/peds.2020-1437
  • Qiu, L., et al. (2020). A Typical Case of Critically Ill Infant of Coronavirus Disease 2019 With Persistent Reduction of T Lymphocytes. Pediatr Infect Dis J. doi.org/10.1097/INF.0000000000002720
  • Qiu, H., et al. (2020). Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. doi:10.1016/s1473-3099(20)30198-5
  • Rahmanzade, R., et al. (2020). Respiratory Distress in Postanesthesia Care Unit: First Presentation of Coronavirus Disease 2019 in a 17-Year-Old Girl: A Case Report. AA Prac, 14(7), e01227. doi.org/10.1213/XAA.0000000000001227
  • Riphagen, S., et al. (2020). Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. doi:10.1016/s0140-6736(20)31094-1
  • See, K. C., et al. (2020). COVID-19: Four Paediatric Cases in Malaysia. Int J Infect Dis.  doi.org/10.1016/j.ijid.2020.03.049
  • Shekerdemian, L. S., et al. (2020). Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr. doi:10.1001/jamapediatrics.2020.1948
  • Shen, Q., et al. (2020). Novel coronavirus infection in children outside of Wuhan, China. Pediatr Pulmonol. doi 10.1002/ppul.24762
  • Schwierzeck, V., et al. (2020). First reported nosocomial outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a pediatric dialysis unit. Clin Infect Dis. doi:10.1093/cid/ciaa491
  • Song, W., et al. (2020). Clinical features of pediatric patients with coronavirus disease (COVID-19). J Clin Virol. doi:10.1016/j.jcv.2020.104377
  • Su, L., et al. (2020). The different clinical characteristics of corona virus disease cases between children and their families in China – the character of children with COVID-19. Emerg Microbes Infect, 9(1), 707-713. doi: https://dx.doi.org/10.1080/22221751.2020.1744483
  • Sun, D., et al. (2020). Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. doi:10.1007/s12519-020-00354-4
  • Tagarro, A., et al. (2020). Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain. JAMA Pediatr. doi 10.1001/jamapediatrics.2020.1346 
  • Talarico, V., et al. (2020). Preliminary epidemiological analysis on children and adolescents with novel coronavirus disease (2019-nCoV) in a central area of Calabria region. Acta Bio-Med. 91(2), 232-233. doi:https://dx.doi.org/10.23750/abm.v91i2.9550
  • Tan, Y. P., et al. (2020). Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. J ClinVirol. doi.org/10.1016/j.jcv.2020.104353
  • Team, C. C.-R. (2020). Coronavirus Disease 2019 in Children – United States, February 12-April 2, 2020. MMWR – Morbidity & Mortality Weekly Report 69(14): 422-426. dx.doi.org/10.15585/mmwr.mm6914e4
  • Turbin, R. E., et al. (2020). Orbital cellulitis, sinusitis and intracranial abnormalities in two adolescents with COVID-19. Orbit, 1-6. doi:https://dx.doi.org/10.1080/01676830.2020.1768560
  • Verdoni, L., et al. (2020). An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. doi:https://dx.doi.org/10.1016/S0140-6736(20)31103-X
  • Wang, Y., et al. (2020). The Risk of Children Hospitalized With Severe COVID-19 in Wuhan. Pediatr Infect Dis J. doi:10.1097/inf.0000000000002739
  • Wei, M., et al. (2020). Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China. Jama. doi: https://dx.doi.org/10.1001/jama.2020.2131
  • Wu, Q., et al. (2020). Co-infection and Other Clinical Characteristics of COVID-19 in Children. Pediatrics, doi.org/10.1542/peds.2020-0961
  • Xiong, X. L., et al. (2020). Comparative study of the clinical characteristics and epidemiological trend of 244 COVID-19 infected children with or without GI symptoms. Gut. doi:10.1136/gutjnl-2020-321486
  • Xu, Y., et al. (2020). Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. doi.org/10.1038/s41591-020-0817-4
  • Yin, X., et al. (2020). A mild type of childhood Covid-19 – A case report. Radiol Infect Dis., doi.org/10.1016/j.jrid.2020.03.004
  • Zhang, B., et al. (2020). Children hospitalized for coronavirus disease 2019 (COVID-19): a multicenter retrospective descriptive study. J Infect. doi:10.1016/j.jinf.2020.04.045
  • Zheng, F., et al. (2020). Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci. doi:10.1007/s11596-020-2172-6
  • Zhu, L., et al. (2020). Clinical characteristics of a case series of children with coronavirus disease 2019. Pediatr Pulmonol. doi.org/10.1002/ppul.24767

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